- Title
- Clinical translation of basic science in asthma
- Creator
- Bardin, Philip G.; Foster, Paul S.
- Relation
- New England Journal of Medicine Vol. 385, Issue October 28, p. 1714-1717
- Publisher Link
- http://dx.doi.org/10.1056/NEJMe2114472
- Publisher
- Massachusetts Medical Society
- Resource Type
- journal article
- Date
- 2021
- Description
- Basic science has enriched our understanding of the pathophysiology of severe asthma. Clinical translation of these discoveries has resulted in biologic therapies that target key components of asthma-related disease pathways. For example, identification and validation of biomarkers such as elevated blood eosinophil counts made it possible to implement tailored biologic treatments targeting the function of cytokines such as interleukin-5, interleukin-4, and interleukin-13.1 The success of these strategies has prompted investigations of other molecules that are active in the pathogenesis of severe asthma. The results of two pertinent trials are reported in this issue of the Journal.
- Subject
- editorial; severe asthma; clinical translation; basic science; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1428209
- Identifier
- uon:38612
- Identifier
- ISSN:0028-4793
- Rights
- New England Journal of Medicine, Bardin, Philip G.; Foster, Paul S., T Clinical translation of basic science in asthma, Vol. 385, Issue October 28, p. 1714-1717, Copyright © (2021) Massachusetts Medical Society. Reprinted with permission. http://dx.doi.org/10.1056/NEJMe2114472.
- Language
- eng
- Full Text
- Reviewed
- Hits: 922
- Visitors: 917
- Downloads: 18
Collections
Goal 3: Good Health and Well-Being
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Author final version | 3 MB | Adobe Acrobat PDF | View Details Download |